Critically ill patients acquire infections during their stay in an intensive care unit (ICU), and the frequency of these infections varies considerably in different populations and clinical settings. The purpose of this study was to determine the antimicrobial sensitivity patterns of Acinetobacter isolated from tracheal aspirate, blood from central venous catheter, peripheral blood, and central venous line swab of patients admitted to the inpatients department at Sylhet MAG Osmani Medical College Hospital Sylhet (SOMCH), Bangladesh over a one-year period from July 2016 to June 2017. A total of 60 samples were studied, of which 9 (15%) were Acinetobacter. Acinetobacter isolated from tracheal aspirates was 21.6%, and blood from a central venous catheter was 16.6%. Isolated Acinetobacter were 100% resistant to Amoxycillin, Cefuroxime, Ceftazidime, Cefepime, and Aztreonam, followed by 88.8% resistant to Ciprofloxacin, Ceftriaxone, and Tazobactam and piperacillin. The rate of resistance to Gentamicin, Amikacin, and Imipenem was found to be 77.7%, 77.7%, and 66.66%, respectively. But all the isolated Acinetobacter were 100% sensitive to Colistin. Antibiotic resistance in isolated Acinetobacter from tracheal aspirates and central venous catheter emphasizes the importance of rationale and judicious antibiotic use based on that institution's antibiotic resistance patterns.The findings of this study will help with a better understanding of the resistance patterns of isolated Acinetobacter and can help in managing patients effectively as well as play a role in developing a strategy to reduce the emergence and spread of antimicrobial-resistant pathogens in medical units.

Keywords: Acinetobacter, Colistin, Resistance.